The museum offers wide-ranging documentation on the processing and transport of salt produced in the saltern of Margherita di Savoia that up to 1879 was called Salina di Barletta. The saltern has been active since the 3rd century B.C. and is the most important and oldest of Italy.

It holds a wide range of objects belonging to industrial archeology: scientific instruments,, scales for weighing, work and harvesting implements, mobile units and carts for transport, samples of various kinds of salt and containers and cases for its commercialization.

The museum also houses objects belonging to the fishing and marine industries, images and maps documentation; illustrative panels of the system for harvesting, transporting and producing salt, models of the area where the ancient salt deposits are found, which belong to the Humid Zone that is protected and is internationally known.

The source waters (salt-bromoiodic waters) that come back from the saltern are recovered and used for therapeutic as well as chemical and pharmaceutical purposes.